Abdul Aziz Bin Abdul Raman

Nanotechnology: Synthesis of Nanostructure Active Pharmaceutical Ingredients for Isoniazid and Griseofulvin by Cryogenic Technology Abdul Aziz Bin Abdul Raman

One of the major challenges in the pharmaceutical industries is to improve the physicochemical properties of newly discovered Active Pharmaceutical Ingredients (API). Improving physicochemical properties of APIs can be achieved through control of particle size distributions during production with the introduction of water-soluble polymers and/or surfactants, which act as additives to prevent particle agglomeration and crystal growth. Venturing into the nano-particle world by producing APIs at nano-scale through nano-particle formation processes are expected to enhance physicochemical properties of APIs. On the other hand, cryogenic and nucleation technologies are promising process that creates highly porous nano-structured particles compared to conventional process such as wet milling and high pressure homogenization which normally lead to degradation in API activities. It can be concluded convincingly, that developed technique is an effective particle formation process for pharmaceutical development (particularly Isoniazid & Griseofulvin) and manufacturing to improve dissolution rates of poorly water soluble APIs.