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Modelirovanie Vzaimodeystviya Antimikrobnykh Peptidov S Membranami: Molekulyarnaya Dinamika Vzaimodeystviya Zervamitsina S Model'nymi Lipidnymi Bisloyami Ol'ga Levtsova Russian edition
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Modelirovanie Vzaimodeystviya Antimikrobnykh Peptidov S Membranami: Molekulyarnaya Dinamika Vzaimodeystviya Zervamitsina S Model'nymi Lipidnymi Bisloyami
Ol'ga Levtsova
Vozrastayushchaya ustoychivost' patogennykh mikroorganizmov k ispol'zuemym antibiotikam yavlyaetsya ser'eznoy meditsinskoy i proizvodstvennoy problemoy. V svyazi s etim ves'ma aktual'nym stanovitsya issledovanie novykh antimikrobnykh agentov, v chastnosti, membran-aktivnykh peptidov s tsel'yu sozdaniya preparatov novogo pokoleniya s zadannoy aktivnost'yu i selektivnost'yu. Sredi membran aktivnykh peptidov osoboy populyarnost'yu pol'zuyutsya peptaiboly. Oni vzaimodeystvuyut s kletochnoy membranoy i obrazuyut ionnyy kanaly, tem samym, narushaya elektro-khimicheskiy balans kletki. V dannoy rabote izuchaetsya predstavitel' klassa peptaibolov zervamitsin IIB, vydelyaemyy iz Emericellopsis salmosynnemata. Na osnove poluchennoy metodom dvumernogo YaMR struktury molekuly bylo provedeno sravnitel'noe izuchenie vzaimodeystviya molekuly zervamitsina IIB s model'nymi membranami prokariot i eukariot. Na posledney stadii byli skonstruirovany i izucheny tri modeli zervamitsinovogo kanala, sostoyashchie iz chetyrekh, pyati i shesti molekul peptida.
| Media | Books Paperback Book (Book with soft cover and glued back) |
| Released | November 15, 2010 |
| ISBN13 | 9783843305587 |
| Publishers | LAP LAMBERT Academic Publishing |
| Pages | 128 |
| Dimensions | 150 × 8 × 225 mm · 209 g |
| Language | German |